Not to nitpick but to me the title of this post is implying that XXY individuals are born female. Generally they’re born male.
What the comment is referring to is likely Swyer Syndrome, where the individual has an XY configuration but a dysfunctional gene in the sex-determining region of the Y chromosome. This means the embryo develops female anatomy and the resulting children tend to identify female, but they lack functional gonadal tissue. It’s estimated to occur at a rate of about 1 in a 100,000 females.
By the by, treatment for these individuals usually involves removing the dysfunctional gonadal tissue as it often becomes cancerous (which often gets misunderstood as “gender reassignment surgery”) and supplemental hormone replacement therapy. They would be affected too by any bans on hormone administration to kids often connected with trans people. One of the reasons why blanket bans should be a no-go regardless of how you feel about any other trans issue.
I think we can safely say that is nitpicking, but it’s informative and correct so I’m all for it!
From my biology lessons 20 years ago, I thought I was taught that it was the presence of a second X chromosome that made a person genetically female, but I could definitely be misremembering. Either way, XXY individuals are usually born male, and Dr Genetics Federation was likely talking about sawyer syndrome (or so google tells me). Thanks for the correction!
Not in humans, no! While in some animals sex determination is purely about X dosage (Drosophila), in humans the Y chromosome is actually sex-determining. In females the second X chromosome actually gets inactivated as a means of gene dosage compensation.
TIL, thanks!
I decided to Google it just to be safe
And yes he is lmao
And 5 time finalist of the Eureka Prize - which sounds impressive even if I’ve never heard of it!
Just saying the word eureka is exciting
Not if you live in north west California, then it’s just a town name.
Isn’t it latin for ‘fetch me my towel’?
According to Wikipedia
“Eureka” comes from the Ancient Greek word εὕρηκα heúrēka, meaning “I have found (it)”, which is the first person singular perfect indicative active of the verb εὑρίσκω heurískō “I find”. It is closely related to heuristic, which refers to experience-based techniques for problem-solving, learning, and discovery.
I was having a civil and boring discussion with someone on a (non-anonymous) forum once about a highly specific technical thing, and then some random person decides to write something along the lines of “I have nothing to add to this conversation, but I just want to point out that the guy you’re talking to is actually an employee of <well known company> :)”
I don’t know if that guy felt any cringe after posting that, but I sure as hell felt it for him. Neither of us really knew how to respond to that, and it kind of just killed the discussion to avoid that awkwardness.
Sometimes I still think about that guy. Is he still vicariously Pretty Woman’ing people? Did he accomplish some of his life goals? I hope so.
Mic drop…
I am curious about the video though
Transphobic BS I believe. But I’m not trawling through fb to find the original.
Is he mixing up people with 3 gonosomes?
Because these are not too rare. It’s one of the more frequent mutations.
But even a person with XXY is a male. Since the male gonosome is considered as a mutation of an X chromosome. Somewhere in the evolution of mammals and other vertebrates (or most likely much earlier) something messed up and created the Y chromosome from an X chromosome. That’s why genetic diseases are usually more frequent in males, since one branch of the X chromosome does not have some backup. It’s simply missing.
So whenever a person has one Y chromosome. It is considered male. The lack of a Y chromosome is considered a female.
This can also be seen in people with genetic disorders, such as three gonosomes. XXX is a female XYY is a male XXY is also a male.
And to everyone’s information: I am for Germany and we do not have two words for sex and gender.
I don’t understand what you English speakers are up to.
I just wrote a comment above but I believe OP is mixing XXY with what the comment was about, which is likely Swyer Syndrome: XY individuals with female anatomy and gonadal dysgenesis. While they have a Y chromosome, a defective sex-determining gene leads to a failure to sexually differentiate into male gonadal tissue and leads to subsequent loss of downstream sex hormone production.
So I assume such people are identified as females at birth. But if their chromosomes indicate that they are male, what’s the gender then?
I think it’s a male then, right? Because when a defect leads to malformations, it still is a malformation. One that people could probably live very well with.
If male and female are assigned purely based on physical anatomy, does it really matter?
No one in that person’s life would consider them male and doctors would treat them based on their sex characteristics - they may have testes but they wouldn’t be external.
I have never been karyotyped and I’m willing to bet most people haven’t either; your sex is assumed based on your outward appearance even when your genitals are not observable.
I really don’t think that having a Y chromosome makes you male when you literally have a vagina, you know? Especially when you could go your whole life without knowing.
If the SRY gene is broken, they’d still physically develop as female, though potentially with some abnormalities, rather than as male. Even leaving gender identity out of it, sex is still more complicated than
if exists Y; then maleBut If I have a construction plan, and this plan is somewhat flawed, but I start building anyway, then I am still building the planned object, but with flaws?
I don’t want to offend anyone. I myself have a genetic defect, much worse if you ask me, than some sexual genetic defect. I can barely consume any fructose without shitting myself. ¯_(ツ)_/¯
I think if we’re going to use the construction plan metaphor, it would be more accurate to say that the builders didn’t get the message to alter the plans. Like if there was a house plan that was designed so it could be a duplex or a single family home by adding or removing one wall. Both options actually exist in the plans for the house at all times (yes, XX still has the genetic code for male anatomy), the SRY gene isn’t the plans to build male anatomy, that’s stored elsewhere, the SRY gene is more like a text to the builder saying “go with option B”. Except in this case the text failed to send, so the builder defaulted to option A.
So at the end of the day, the builder doesn’t put the wall in and builds a single family home, not a duplex. The owner may have wanted a duplex, but that isn’t what got built. So is it a duplex or not? I would lean towards saying no, but we’re not talking about houses, we’re talking about people, so it should probably just be their call
Being a president of something doesn’t mean crap though.
It does if it’s as prestigious and well known as the International Genetics Federation.
It doesn’t. Administrative work requires different set of skills of knowledge from scientist work.
Well, he has a doctorate and has been cited over 13,000 times. So for this particular institution, it absolutely does.
So he should’ve bragged about citations. Because, once again, being a president of something doesn’t mean shit.
I’m going to make a new club right now and call it the International Institute for Genetic Study and name myself the president.
