I’ve only played some of the starter set as a player, so I can’t provide a ton of insight there. I think the biggest thing is making sure the players are bought into the core concept of the game and the system. It is not 5e, doesn’t play like 5e. Combat is far more abstract, and for some that becomes a barrier.

Hopefully other GMs will chime in with advice on running it, but making sure it’s a good fit for the group is where I go to first.